Publications

  1. Liu L, Inoki A, Fan K, Mao F, Shi G, Jin X, Zhao M, Ney G, Jones MA, Sun S, Dou Y, Inoki K, Qi L, Li Q. ER associated degradation preserves hematopoietic stem cell quiescence and self-renewal by restricting mTOR activity. Blood. 2020 Nov 4. PubMed PMID: 33150381.

  2. Xu, L., Liu, X., Peng, F., Zhang, W., Zheng, L., Ding, Y., Gu, T., Lv, K., Wang, J., Ortinau, L.C., Hu, T., Shi, C., Shi, G., Shang, G., Sun, S., Iwawaki, T., Ji, Y., Li, W., Rosen, J.M., Zhang, X.H.F., Park, D., Adoro, S., Catic, A., Wei, T., Qi, L., Nakada, D., and Chen, X. Protein quality control through endoplasmic reticulum-associated degradation maintains haematopoietic stem cell identity and niche interactions. Nat Cell Biol. 2020 Oct;22(10):1162-1169. PubMed PMID: 32958856.

  3. Sun S, Kelekar S, Kliewer S, Mangelsdorf D. The orphan nuclear receptor SHP regulates ER stress response by inhibiting XBP1s degradation. Genes & development. 2019 Aug 1;33(15-16):1083-1094. PubMed PMID: 31296559; PubMed Central PMCID: PMC6672048.

  4. Ji Y*, Sun S*, Shrestha N, Darragh LB, Shirakawa J, Xing Y, He Y, Carboneau BA, Kim H, An D, Ma M, Oberholzer J, Soleimanpour SA, Gannon M, Liu C, Naji A, Kulkarni RN, Wang Y, Kersten S, Qi L. Toll-like receptors TLR2 and TLR4 block the replication of pancreatic β cells in diet-induced obesity. Nat Immunol. 2019 Jun;20(6):677-686. PubMed PMID: 31110312; PubMed Central PMCID: PMC6531334. (*, contributed equally)

  5. Bhattacharya A, Sun S, Wang H, Liu M, Long Q, Yin L, Kersten S, Zhang K, Qi L. Hepatic Sel1L-Hrd1 ER-associated degradation (ERAD) manages FGF21 levels and systemic metabolism via CREBH. EMBO J. 2018 Nov 15;37(22)PubMed PMID: 30389665; PubMed Central PMCID: PMC6236331.

  6. Shi G, Somlo DRM, Kim GH, Prescianotto-Baschong C, Sun S, Beuret N, Long Q, Rutishauser J, Arvan P, Spiess M, Qi L. ER-associated degradation is required for vasopressin prohormone processing and systemic water homeostasis. J Clin Invest. 2017 Oct 2;127(10):3897-3912. PubMed PMID: 28920920; PubMed Central PMCID: PMC5617659.

  7. Coate KC, Hernandez G, Thorne CA, Sun S, Le TDV, Vale K, Kliewer SA, Mangelsdorf DJ. FGF21 Is an Exocrine Pancreas Secretagogue. Cell Metab. 2017 Feb 7;25(2):472-480. PubMed PMID: 28089565; PubMed Central PMCID: PMC5299054.

  8. Sun S#, Lourie R, Cohen SB, Ji Y, Goodrich JK, Poole AC, Ley RE, Denkers EY, McGuckin MA, Long Q, Duhamel GE, Simpson KW, Qi L#. Epithelial Sel1L is required for the maintenance of intestinal homeostasis. Mol Biol Cell. 2016 Feb 1;27(3):483-90. PubMed PMID: 26631554; PubMed Central PMCID: PMC4751599. (#, co-corresponding authors)

  9. Sun S*, Shi G*, Sha H, Ji Y, Han X, Shu X, Ma H, Inoue T, Gao B, Kim H, Bu P, Guber RD, Shen X, Lee AH, Iwawaki T, Paton AW, Paton JC, Fang D, Tsai B, Yates JR 3rd, Wu H, Kersten S, Long Q, Duhamel GE, Simpson KW, Qi L. IRE1α is an endogenous substrate of endoplasmic-reticulum-associated degradation. Nat Cell Biol. 2015 Dec;17(12):1546-55. PubMed PMID: 26551274; PubMed Central PMCID: PMC4670240. (*, contributed equally)

  10. Liu X, Sadhukhan S, Sun S, Wagner GR, Hirschey MD, Qi L, Lin H, Locasale JW. High-Resolution Metabolomics with Acyl-CoA Profiling Reveals Widespread Remodeling in Response to Diet. Mol Cell Proteomics. 2015 Jun;14(6):1489-500. PubMed PMID: 25795660; PubMed Central PMCID: PMC4458715.

  11. Sha H, Sun S, Francisco AB, Ehrhardt N, Xue Z, Liu L, Lawrence P, Mattijssen F, Guber RD, Panhwar MS, Brenna JT, Shi H, Xue B, Kersten S, Bensadoun A, Péterfy M, Long Q, Qi L. The ER-associated degradation adaptor protein Sel1L regulates LPL secretion and lipid metabolism. Cell Metab. 2014 Sep 2;20(3):458-70. PubMed PMID: 25066055; PubMed Central PMCID: PMC4156539.

  12. Ji Y*, Sun S*, Goodrich JK, Kim H, Poole AC, Duhamel GE, Ley RE, Qi L. Diet-induced alterations in gut microflora contribute to lethal pulmonary damage in TLR2/TLR4-deficient mice. Cell Rep. 2014 Jul 10;8(1):137-49. PubMed PMID: 24953658; PubMed Central PMCID: PMC4103790. (*, contributed equally)

  13. Sun S*, Shi G*, Han X, Francisco AB, Ji Y, Mendonça N, Liu X, Locasale JW, Simpson KW, Duhamel GE, Kersten S, Yates JR 3rd, Long Q, Qi L. Sel1L is indispensable for mammalian endoplasmic reticulum-associated degradation, endoplasmic reticulum homeostasis, and survival. Proc Natl Acad Sci U S A. 2014 Feb 4;111(5):E582-91. PubMed PMID: 24453213; PubMed Central PMCID: PMC3918815. (*, contributed equally)

  14. Ji Y, Sun S, Xia S, Yang L, Li X, Qi L. Short term high fat diet challenge promotes alternative macrophage polarization in adipose tissue via natural killer T cells and interleukin-4. J Biol Chem. 2012 Jul 13;287(29):24378-86. PubMed PMID: 22645141; PubMed Central PMCID: PMC3397864.

  15. Sun S, Xia S, Ji Y, Kersten S, Qi L. The ATP-P2X7 signaling axis is dispensable for obesity-associated inflammasome activation in adipose tissue. Diabetes. 2012 Jun;61(6):1471-8. PubMed PMID: 22415881; PubMed Central PMCID: PMC3357307.

  16. Ji Y, Sun S, Xu A, Bhargava P, Yang L, Lam KS, Gao B, Lee CH, Kersten S, Qi L. Activation of natural killer T cells promotes M2 Macrophage polarization in adipose tissue and improves systemic glucose tolerance via interleukin-4 (IL-4)/STAT6 protein signaling axis in obesity. J Biol Chem. 2012 Apr 20;287(17):13561-71. PubMed PMID: 22396530; PubMed Central PMCID: PMC3340139.

  17. Sun S, Ji Y, Kersten S, Qi L. Mechanisms of inflammatory responses in obese adipose tissue. Annu Rev Nutr. 2012 Aug 21;32:261-86. PubMed PMID: 22404118; PubMed Central PMCID: PMC4041712.

  18. Yang L, Xue Z, He Y, Sun S, Chen H, Qi L. A Phos-tag-based approach reveals the extent of physiological endoplasmic reticulum stress. PLoS One. 2010 Jul 16;5(7):e11621. PubMed PMID: 20661282; PubMed Central PMCID: PMC2905412.

  19. He Y, Sun S, Sha H, Liu Z, Yang L, Xue Z, Chen H, Qi L. Emerging roles for XBP1, a sUPeR transcription factor. Gene Expr. 2010;15(1):13-25. PubMed PMID: 21061914; PubMed Central PMCID: PMC3374844.

  20. Wong EW, Sun S, Li MW, Lee WM, Cheng CY. 14-3-3 Protein regulates cell adhesion in the seminiferous epithelium of rat testes. Endocrinology. 2009 Oct;150(10):4713-23. PubMed PMID: 19608648; PubMed Central PMCID: PMC2754685.

  21. Sun S, Wong EW, Li MW, Lee WM, Cheng CY. 14-3-3 and its binding partners are regulators of protein-protein interactions during spermatogenesis. J Endocrinol. 2009 Sep;202(3):327-36. PubMed PMID: 19366886; PubMed Central PMCID: PMC2804912.